Name: DNA Methylation Plus Test
Brand: GetTested
SKU: DNAMP
Price: 22490 INR
Availability: InStock
Rating: NaN (100 reviews)

CUBN (Cubilin) is a multifunctional receptor protein involved in the absorption and transport of key nutrients, including vitamin B12 and various proteins such as albumin. It plays a vital role in the kidneys and intestines, where it helps reabsorb filtered proteins and supports nutrient uptake. In the kidney, CUBN works alongside megalin to maintain protein balance, while in the gut, it is essential for the efficient transport of vitamin B12, supporting normal metabolism and cellular function.

CUBN

MTHFR (Methylenetetrahydrofolate Reductase): MTHFR is an enzyme that plays a key role in folate metabolism and the regulation of homocysteine levels. It converts 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate, facilitating the remethylation of homocysteine to methionine — a precursor to S-adenosylmethionine (SAM), the body’s main methyl donor. Variants in the MTHFR gene, such as C677T and A1298C, can influence enzyme activity, potentially disrupting folate metabolism, increasing homocysteine levels, and affecting methylation-dependent processes like DNA methylation and neurotransmitter synthesis.

MTHFR

FUT2 (Fucosyltransferase 2) is a gene that encodes an enzyme involved in the synthesis of histo-blood group antigens and the determination of secretor status. It catalyses the transfer of fucose to specific molecules, enabling the production of glycoproteins and glycolipids found in bodily fluids and epithelial tissues. FUT2 activity influences the expression of the H antigen — a key precursor to ABO blood group antigens — and plays a critical role in whether these antigens are present in secretions like saliva.

FUT2

MTR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase): MTR is a critical enzyme involved in the remethylation pathway of homocysteine metabolism. It catalyses the transfer of a methyl group from 5-methyltetrahydrofolate (5-MTHF) to homocysteine, producing methionine and tetrahydrofolate (THF). Methionine is a precursor for S-adenosylmethionine (SAM), a universal methyl donor essential for various methylation reactions in the body, including DNA methylation, neurotransmitter synthesis, and histone modification. Proper MTR activity is vital for maintaining normal homocysteine levels and supporting cellular methylation processes. Dysregulation of MTR, often due to genetic mutations or deficiencies, can impact these critical functions.

The TCN2 gene encodes transcobalamin II, a protein responsible for transporting vitamin B12 (cobalamin) from the bloodstream into cells. Once vitamin B12 is absorbed in the gut, it must bind to transcobalamin to be delivered to tissues where it is used for DNA synthesis, red blood cell formation, and neurological function. Genetic variations in TCN2 can reduce the efficiency of B12 transport, potentially leading to functional B12 deficiency even when blood levels appear normal. This may contribute to symptoms like fatigue, cognitive changes, or elevated homocysteine.

TCN2

FOLH1 (Folate Hydrolase 1), also known as Prostate-Specific Membrane Antigen (PSMA), is a gene involved in folate metabolism and the activation of folate for DNA synthesis and repair. It plays a key role in cell growth and division. FOLH1 is notably expressed in prostate cancer cells, making it a valuable target for cancer diagnosis and therapy.

FOLH1

The MTHFS gene encodes methenyltetrahydrofolate synthetase, an enzyme involved in folate metabolism. It plays a crucial role in maintaining the pool of active folate derivatives used for methylation, DNA synthesis, and neurotransmitter production. MTHFS regulates the conversion of various folate forms and helps maintain the balance of one-carbon units essential for cellular function. Variants in this gene may disrupt folate recycling, potentially affecting methylation pathways and contributing to issues such as impaired detoxification, fatigue, or mood imbalance.

MTHFS

DHFR (Dihydrofolate Reductase) is an enzyme that holds a crucial role in DNA synthesis and repair. It catalyzes the conversion of dihydrofolate into tetrahydrofolate, an essential cofactor for the production of purines, thymidylate, and certain amino acids. This process is vital for cell growth and division, making DHFR a key target in cancer treatment, where inhibitors such as methotrexate block its activity to stop rapidly dividing cells.

DHFR

The TYMS gene encodes thymidylate synthase, a crucial enzyme involved in the synthesis of thymidine, one of the four nucleotides essential for DNA replication and repair. This enzyme depends on active folate (5,10-methylene-THF) to function effectively, closely linking TYMS to folate metabolism. Variants in the TYMS gene can influence folate availability at the cellular level and may modify the body's response to folate or folate-based treatments. Such alterations may contribute to impaired DNA synthesis, increased vulnerability to certain diseases, or varied responses to chemotherapy or supplementation.

TYMS

MTHFD1 (Methylenetetrahydrofolate Dehydrogenase 1): MTHFD1 is a crucial enzyme in the folate metabolism pathway, catalysing the conversion of tetrahydrofolate (THF) derivatives into forms utilised for synthesising DNA, RNA, and amino acids. It plays an essential role in one-carbon metabolism, affecting cellular methylation reactions and nucleotide production. Mutations or dysregulation of MTHFD1 can disrupt folate metabolism and are linked to a higher risk of congenital defects, cardiovascular diseases, and cancer.

MTHFD1

MTRR (Methionine Synthase Reductase): MTRR is an enzyme that plays a vital role in regenerating methylcobalamin, supporting the ongoing function of MTR in homocysteine metabolism. It is crucial for maintaining proper methionine levels and normal DNA synthesis. Mutations in MTRR are associated with homocystinuria, which can lead to developmental and neurological complications. Understanding MTRR function offers insights into potential therapies for genetic disorders.

MTRR

The MTHFD1L gene encodes a mitochondrial enzyme involved in the folate cycle and one-carbon metabolism, specifically in the conversion of formate to 10-formyl-THF. This process supports purine synthesis and methylation reactions, which are essential for DNA and RNA production and cellular repair. Genetic variations in MTHFD1L can affect mitochondrial folate metabolism and have been associated with an increased risk of neural tube defects, cardiovascular issues, and impaired methylation. It plays a complementary role to the cytosolic MTHFD1 gene but operates within the mitochondria.

MTHFD1L

SHMT1 (Serine Hydroxymethyltransferase 1): SHMT1 is an enzyme that catalyses the conversion of serine and tetrahydrofolate into glycine and methylenetetrahydrofolate. This process is essential for nucleotide synthesis and methylation reactions, which support DNA replication and repair. SHMT1 plays a key role in cell growth and genetic stability, and its activity in folate metabolism is linked to cancer risk and neurological disorders.

SHMT1

What is measured in the Folate Cycle?

GNMT (Glycine N-Methyltransferase) is a crucial enzyme involved in methionine metabolism and liver detoxification. It helps regulate homocysteine levels by converting excess methionine into sarcosine, preventing harmful accumulation of methionine and promoting liver health. Dysfunction of GNMT is linked to liver disorders such as fatty liver disease and liver cancer. Ongoing research underscores GNMT’s protective role against liver toxicity and its potential as a biomarker for evaluating liver health.

GNMT

AHCY: Encodes the enzyme adenosylhomocysteinase, which plays a crucial role in converting S-adenosylhomocysteine into homocysteine, a vital step in the body's methylation processes and detoxification.

AHCY

BHMT (Betaine-Homocysteine S-Methyltransferase): BHMT is an enzyme that indicates the body’s capability to metabolise homocysteine, a process vital for cardiovascular and neurological health. BHMT catalyses the conversion of homocysteine to methionine using betaine as a methyl donor. Dysregulation of BHMT can cause elevated homocysteine levels, which are linked with cardiovascular diseases and other health issues.

BHMT

COMT (Catechol-O-Methyltransferase): COMT is an enzyme that plays a crucial role in the metabolism of catecholamines, including dopamine, epinephrine, and norepinephrine. It is essential for regulating neurotransmitter levels in the brain and is associated with psychiatric disorders such as schizophrenia. COMT also influences the body's pain response and has been studied in connection with pain sensitivity and various mental health conditions.

COMT

MAT1A (Methionine Adenosyltransferase I, Alpha) is an enzyme that produces S-adenosylmethionine (SAMe), the body’s primary methyl donor for key metabolic processes. It plays a central role in methionine metabolism, influencing gene regulation, cell growth, and detoxification. Reduced MAT1A activity is linked to liver disorders such as cirrhosis and hepatocellular carcinoma.

MAT1A

CHDH (Choline Dehydrogenase) is a crucial enzyme involved in choline metabolism, converting choline into betaine. This conversion aids the production of acetylcholine, an essential neurotransmitter, and helps regulate homocysteine levels, which is vital for cardiovascular health. CHDH activity impacts choline availability, influencing liver function, brain development, and nervous system health. Studying CHDH can provide valuable insights into nutritional requirements and interventions for metabolic disorders.

CHDH

PEMT (Phosphatidylethanolamine N-Methyltransferase): PEMT is an enzyme that converts phosphatidylethanolamine into phosphatidylcholine in the liver, a crucial step for maintaining the structure of cell membranes and facilitating VLDL secretion. Its activity influences liver function, fat metabolism, and choline requirements, with imbalances associated with liver and cardiovascular disease risk.

PEMT

DNMT3B (DNA Methyltransferase 3 Beta) is a gene that encodes an enzyme involved in DNA methylation — a key epigenetic mechanism that regulates gene expression. DNMT3B plays a vital role in development and has been associated with conditions such as ICF syndrome and various cancers.

DNMT3B

What is measured in the Methionine Cycle?

CBS (Cystathionine beta-synthase): CBS is an enzyme crucial for sulfur metabolism, playing a key role in converting homocysteine into cysteine. This process aids in the production of glutathione, an important antioxidant that protects cells from oxidative stress. CBS also takes part in the transsulfuration pathway, which regulates sulfur-containing amino acids and hydrogen sulfide—a signalling molecule involved in various physiological functions. Proper CBS activity is essential for maintaining cellular redox balance, vascular health, and neurotransmitter regulation. Dysregulation of CBS is associated with metabolic disorders such as homocystinuria and cardiovascular diseases.

The PDXK gene encodes the enzyme pyridoxal kinase, which is crucial for converting vitamin B6 into its active form, pyridoxal-5′-phosphate (PLP). PLP acts as a coenzyme in over 100 enzymatic reactions, many involved in amino acid metabolism, neurotransmitter synthesis, and energy production. Variants in the PDXK gene may disrupt this conversion, potentially causing a functional vitamin B6 deficiency despite adequate B6 intake. Altered PLP levels have been associated with neurological symptoms, fatigue, and mood disorders.

PDXK

What is measured in the Transsulfuration?

Our DNA Methylation test is a home test kit. After placing your order, we will send you a kit containing everything you need to collect your saliva sample. Simply return your sample to us using the pre-paid envelope provided.

How is the DNA Methylation Plus Test conducted?

This test is ideal for individuals seeking a deeper understanding of their genetic predispositions related to mood, energy, detoxification, hormonal balance, and overall health. It can be particularly beneficial for those experiencing chronic fatigue, mood disorders, or with a family history of cardiovascular or neurological conditions.

Who should consider taking this test?

Once we receive your sample, you can expect to get your results within 6-8 weeks.

How fast will I get my results?

The test can be collected at any time of the day.

When should I take the test?

We use genotyping, a reliable method that looks at key points in your DNA called SNPs.

What testing method does your DNA test use?

Your personal data will be used to process your order, support your experience throughout this website, and for other purposes described in our

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The home test was incredibly simple to use, with clear and easy-to-follow instructions. The results were precise and well-explained. I also appreciated the option to get my questions answered about the results.

I found the home test process seamless and hassle-free. The instructions were straightforward, and the results were presented in a very professional and clear manner. Having the chance to clarify my doubts made it even better.

Using the home test was a breeze. The directions were easy to understand, and the detailed results were shared promptly. It was comforting to know that I could ask questions about the results and get quick responses.

The home testing kit was simple to use, and the instructions were clear. The detailed report was very informative, and I felt reassured by the opportunity to discuss the results with a professional.

The home test was well-designed and came with clear, step-by-step instructions. The results were detailed and easy to interpret. I also appreciated being able to ask follow-up questions about my report.

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DNA Methylation Plus Test

What is measured in the Folate Cycle?

What is measured in the Methionine Cycle?

What is measured in the Transsulfuration?

FAQ

Example report

Reviews

Trusted by over 100.000+ customers

Your Cart

DNA Methylation Plus Test

What is measured in the Folate Cycle?

What is measured in the Methionine Cycle?

What is measured in the Transsulfuration?

FAQ

Example report

Reviews

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Trusted by over 100.000+ customers

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