ACKR1 (Atypical Chemokine Receptor 1): ACKR1 is a receptor that regulates chemokine activity in the body. Previously known as DARC (Duffy Antigen Receptor for Chemokines), ACKR1 functions as a decoy receptor, binding chemokines without initiating intracellular signaling. By capturing chemokines, it helps modulate immune responses and control inflammation, thereby protecting tissues from excessive damage. Variations in ACKR1 are associated with differences in susceptibility to infections and the severity of inflammatory diseases.