Histamine-producing bacteria
Histamine-producing bacteria are gut microbes capable of converting the amino acid histidine into histamine, a biogenic amine that plays a central role in immune responses and allergic reactions. While histamine is a necessary signaling molecule, excess production in the gut can contribute to symptoms resembling allergies, such as rashes, headaches, or digestive discomfort. These bacteria may flourish in the presence of chronic stress, poor gut barrier function, or diets rich in histidine-containing foods. Elevated levels are associated with conditions like histamine intolerance or pseudoallergies. Maintaining a balanced microbiome and proper gut barrier integrity may help reduce histamine load from microbial sources.
Description
These are particular gut microbes that transform the amino acid histidine into histamine, which can affect immune function and inflammatory reactions.
Excessive histamine production by gut bacteria can lead to symptoms like bloating, skin reactions, headaches, or food intolerances, even in the absence of a classical allergy.
A high percentage indicates an overgrowth of histamine-producing bacteria, which could suggest dysbiosis, increased intestinal permeability ("leaky gut"), or histamine intolerance.
It indicates that these microbes are neither overactive nor abundant at present, which could be beneficial for people sensitive to histamine.
Diet, chronic stress, and microbial imbalance in the gut all contribute. Reducing histamine-rich foods and improving gut health may help regulate histamine production.
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